Table 3.
Significant associations between variants on NLRP3 and CASP1 with asthma, severity asthma symptoms, IL-13 production, anti-Bt IgE and SPT for Bt.
| Gene | SNP | Model | Geno | Aff | Unaff | ORa | CI 95% | P-value* |
|---|---|---|---|---|---|---|---|---|
| Asthma | ||||||||
| NLRP3 | rs12137901 | Additive | C/C | 33 | 79 | 1.28 | 1.04–1.57 | 0.016 |
| C/T | 111 | 359 | ||||||
| T/T | 116 | 457 | ||||||
| NLRP3 | rs4925648 | Additive | T/T | 11 | 11 | 1.5 | 1.14–1.98 | 0.005 |
| T/C | 63 | 183 | ||||||
| C/C | 186 | 696 | ||||||
| NLRP3 | rs72553860 | Additive | G/G | 28 | 51 | 1.38 | 1.11–1.72 | 0.004 |
| G/A | 104 | 335 | ||||||
| A/A | 129 | 509 | ||||||
| NLRP3 | rs55914518 | Additive | A/A | 1 | 0 | 1.85 | 1.04–3.29 | 0.034 |
| A/G | 17 | 35 | ||||||
| G/G | 243 | 860 | ||||||
| NLRP3 | rs12130711 | Additive | T/T | 12 | 75 | 0.78 | 0.62–0.98 | 0.038 |
| T/C | 101 | 369 | ||||||
| C/C | 148 | 451 | ||||||
| NLRP3 | rs36021952 | Additive | A/A | 2 | 12 | 0.69 | 0.49–0.98 | 0.038 |
| A/G | 42 | 190 | ||||||
| G/G | 216 | 688 | ||||||
| NLRP3 | rs72771992 | Additive | G/G | 3 | 18 | 0.67 | 0.48–0.94 | 0.019 |
| G/T | 37 | 174 | ||||||
| T/T | 219 | 697 | ||||||
| NLRP3 | rs56383829 | Additive | T/T | 52 | 236 | 0.82 | 0.67–0.99 | 0.046 |
| T/C | 134 | 436 | ||||||
| C/C | 75 | 223 | ||||||
| NLRP3 | rs74154644 | Additive | T/T | 2 | 12 | 0.69 | 0.49–0.98 | 0.038 |
| T/C | 42 | 190 | ||||||
| C/C | 217 | 692 | ||||||
| CASP1 | rs7925706 | Additive | T/T | 8 | 9 | 1.47 | 1.11–1.96 | 0.008 |
| T/C | 65 | 185 | ||||||
| C/C | 177 | 675 | ||||||
| Severity asthma symptoms | ||||||||
| NLRP3 | rs4925654 | Additive | A/A | 3 | 45 | 0.62 | 0.44–0.88 | 0.009 |
| A/G | 37 | 357 | ||||||
| G/G | 101 | 613 | ||||||
| NLRP3 | rs12728998 | Additive | T/T | 2 | 34 | 0.68 | 0.48–0.98 | 0.042 |
| T/C | 35 | 321 | ||||||
| C/C | 104 | 660 | ||||||
| IL-13 production in Blomia tropicalis-stimulated blood cell cultures | ||||||||
| NLRP3 | rs4378247 | Additive | C/C | 0 | 59 | 0.39 | 0.22–0.67 | 0.0004 |
| C/T | 15 | 394 | ||||||
| T/T | 50 | 570 | ||||||
| NLRP3 | rs12565738 | Additive | T/T | 1 | 67 | 0.41 | 0.24–0.70 | 0.001 |
| T/C | 14 | 385 | ||||||
| C/C | 53 | 588 | ||||||
| NLRP3 | rs45624634 | Additive | A/A | 0 | 10 | 0.24 | 0.09–0.65 | 0.004 |
| A/C | 4 | 209 | ||||||
| C/C | 64 | 821 | ||||||
| NLRP3 | rs7525979 | Additive | T/T | 0 | 33 | 0.38 | 0.19–0.75 | 0.006 |
| T/C | 9 | 268 | ||||||
| C/C | 59 | 739 | ||||||
| Anti-Blomia tropicalis IgE | ||||||||
| NLRP3 | rs116096527 | Additive | A/A | 0 | 2 | 2.25 | 1.13–4.48 | 0.043 |
| A/G | 17 | 10 | ||||||
| G/G | 383 | 756 | ||||||
| SPT for Blomia tropicalis | ||||||||
| NLRP3 | rs4925659 | Additive | A/A | 25 | 69 | 1.3 | 1.05–1.61 | 0.021 |
| A/G | 117 | 334 | ||||||
| G/G | 118 | 495 | ||||||
| CASP1 | rs79180143 | Additive | A/A | 21 | 74 | 0.79 | 0.63–0.99 | 0.046 |
| A/C | 81 | 355 | ||||||
| C/C | 154 | 446 | ||||||
Geno, genotype; Aff, affected; Unaff, no affected; OR, odds ratio; CI, confidence interval.
a
Adjusted by gender, age, helminth infection, ancestry markers.
*
P-value corrected.