Table 4.

Possible mechanisms where by SNPs on NLRP3 and CASP1 may affect these genes expression, according to rSNPBase.

Gene	CHR	SNP	PR	DR	RNA BPMR
NLRP3	1	rs12137901	Yes	No	No
NLRP3	1	rs4925659	Yes	No	No
NLRP3	1	rs72553860	Yes	No	No
NLRP3	1	rs4925648	Yes	No	No
NLRP3	1	rs36021952	Yes	No	No
NLRP3	1	rs72771992	Yes	No	No
NLRP3	1	rs74154644	Yes	No	No
NLRP3	1	rs56383829	No	Yes	No
CASP1	11	rs79180143	Yes	No	Yes
CASP1	11	rs7925706	Yes	No	Yes

CHR, chromosome; SNP, single nucleotide polymorphism; PR, Proximal regulation; DR, Distal regulation; BPMR, binding protein mediated regulation.