Table 5.
Haplotype analysis between rs72553860, rs12137901, rs36021952 and rs74154644 on asthma risk and between rs45624634, rs12565738, rs7525979 and rs4378247 in decreasing IL-13 production Bt-stimulated, both in NLRP3 gene.
| Frequencies |
||||||||
|---|---|---|---|---|---|---|---|---|
| Haplotype | rs72553860 | rs12137901 | rs36021952 | rs74154644 | Case | Control | Odds Ratioa/95% Confidence interval | P-value |
| Reference | A | T | G | C | 0.57 | 0.55 | 1 | – |
| Haplotype association with risk for asthma | ||||||||
| 1 asthma | G | C | G | C | 0.19 | 0.25 | 1.43 (1.09–1.87) | 0.011 |
| 2 asthma | G | C | – | C | 0.23 | 0.21 | 1.39 (1.09–1.77) | 0.008 |
| 3 asthma | G | C | G | – | 0.23 | 0.22 | 1.38 (1.08–1.76) | 0.009 |
| 4 asthma | G | C | – | – | 0.26 | 0.24 | 1.37 (1.10–1.70) | 0.005 |
| Happlotype | rs45624634 | rs12565738 | rs7525979 | rs4378247 | Case | Control | Odds Ratioa/95% Confidence interval | P-value |
| Reference | C | C | C | T | 0.48 | 0.47 | 1 | – |
| Haplotype association with IL-13 | ||||||||
| 1 IL-13 | C | T | C | – | 0.12 | 0.13 | 0.53 (0.29–0.98) | 0.042 |
| 2 IL-13 | C | C | T | – | 0.12 | 0.13 | 0.41 (0.21–0.81) | 0.011 |
| 3 IL-13 | A | T | C | – | 0.08 | 0.09 | 0.26 (0.09–0.71) | 0.009 |
| 4 IL-13 | C | C | T | T | 0.09 | 0.1 | 0.13 (0.03–0.56) | 0.006 |
| 5 IL-13 | A | T | C | T | 0.06 | 0.07 | 0.11 (0.01–0.80) | 0.030 |
a
Adjusted for confounding variables.