Demyelination in ILC2−/− Mice Following Adoptive Transfer of ILC2s
Bone-marrow-derived ILC2s were isolated from naive WT mice and transferred IV into recipient ILC2−/− mice. Fourteen days postadoptive transfer, recipient ILC2−/− mice were infected ocularly with HSV-IL-2. On day 14 PI, brain, spinal cord, and ON were collected, fixed, sectioned, and stained with LFB. Representative photomicrographs are shown. Arrows indicate areas of demyelination. ×10 objective lens was used.