Table 4.
The performance of BTMs and miRNA Index1.
| microRNA | Cutoff | AUC (95% CI) |
p value | Designed Sensitivity (%) | Specificity (%) | Accuracy (%) | True positive | True negative | False positive | False negative |
|---|---|---|---|---|---|---|---|---|---|---|
| Training cohort | ||||||||||
| Osteoporosis versus Healthy | ||||||||||
| tPINP | 46.27 | 0.61(0.53–0.68) | 0.009 | 80.00 | 42.06 | 57.45 | 69 | 53 | 73 | 17 |
| β-CTx | 0.25 | 0.62(0.54–0.70) | 0.040 | 80.00 | 31.90 | 51.41 | 69 | 40 | 86 | 17 |
| P+C | 0.18 | 0.62(0.55-0.70) | 0.003 | 80.00 | 36.51 | 54.15 | 69 | 46 | 80 | 17 |
| Index1 | –0.89 | 0.86(0.81–0.91) | <0.001 | 80.00 | 76.19 | 77.74 | 69 | 96 | 30 | 17 |
| Osteoporosis versus Osteopenia | ||||||||||
| tPINP | 45.48 | 0.65(0.56–0.73) | 0.001 | 80.00 | 40.79 | 61.61 | 69 | 31 | 45 | 17 |
| β-CTx | 0.25 | 0.57(0.49–0.66) | 0.108 | 80.00 | 30.26 | 56.67 | 69 | 23 | 53 | 17 |
| P+C | 0.18 | 0.60(0.51–0.69) | 0.028 | 80.00 | 28.95 | 56.05 | 69 | 22 | 54 | 17 |
| Index1 | –0.89 | 0.80(0.72–0.87) | <0.001 | 80.00 | 76.32 | 78.27 | 69 | 58 | 18 | 17 |
| Osteopenia versus Healthy | ||||||||||
| tPINP | 72.82 | 0.52(0.44–0.60) | 0.598 | 80.00 | 19.05 | 41.98 | 61 | 24 | 102 | 15 |
| β-CTx | 0.23 | 0.54(0.46–0.62) | 0.329 | 80.00 | 23.81 | 44.95 | 61 | 30 | 96 | 15 |
| P+C | 0.11 | 0.52(0.44–0.61) | 0.585 | 80.00 | 25.40 | 45.94 | 61 | 32 | 94 | 15 |
| Index1 | –2.58 | 0.58(0.50–0.66) | 0.071 | 80.00 | 36.51 | 52.87 | 61 | 46 | 80 | 15 |
| Validation cohort | ||||||||||
| Osteoporosis versus Healthy | ||||||||||
| tPINP | 41.80 | 0.74(0.64–0.83) | <0.001 | 80.00 | 57.14 | 67.69 | 38 | 32 | 24 | 10 |
| β-CTx | 0.27 | 0.78(0.69–0.87) | <0.001 | 80.00 | 57.14 | 67.69 | 38 | 32 | 24 | 10 |
| P+C | 0.24 | 0.79(0.70–0.88) | <0.001 | 80.00 | 67.86 | 73.46 | 38 | 38 | 18 | 10 |
| Index1 | –1.44 | 0.85(0.79–0.92) | <0.001 | 80.00 | 66.07 | 72.50 | 38 | 37 | 19 | 10 |
| Osteoporosis vs Osteopenia | ||||||||||
| tPINP | 42.07 | 0.50(0.39–0.62) | 0.961 | 80.00 | 21.43 | 48.46 | 38 | 12 | 44 | 10 |
| β-CTx | 0.21 | 0.58(0.46–0.69) | 0.184 | 80.00 | 21.43 | 48.46 | 38 | 12 | 44 | 10 |
| P+C | 0.23 | 0.56(0.45–0.67) | 0.309 | 80.00 | 30.36 | 53.27 | 38 | 17 | 39 | 10 |
| Index1 | –1.44 | 0.76(0.67–0.85) | <0.001 | 80.00 | 55.36 | 66.73 | 38 | 31 | 25 | 10 |
| Osteopenia vs Healthy | ||||||||||
| tPINP | 41.51 | 0.73(0.64–0.83) | <0.001 | 80.00 | 57.14 | 68.57 | 45 | 32 | 24 | 11 |
| β-CTx | 0.26 | 0.72(0.63–0.82) | <0.001 | 80.00 | 57.14 | 68.57 | 45 | 32 | 24 | 11 |
| P+C | 0.16 | 0.75(0.66–0.84) | <0.001 | 80.00 | 58.93 | 69.47 | 45 | 33 | 23 | 11 |
| Index1 | –3.44 | 0.65(0.54–0.75) | 0.008 | 80.00 | 37.50 | 58.75 | 45 | 21 | 35 | 11 |
Note: Designed sensitivity#: the performance was considered by defining a cutoff value corresponding to fixing the sensitivity to 80.00%. P+C: the logistical model of serum tPINP and β-CTx.
AUC, area under the ROC curve; BTM, bone turnover marker; CI, confidence interval; miRNA, microRNA; ROC, receiver operating characteristic.