Table 2.
Profile of mutations during the process of antibiotic-induced resistance.
| 0 × MICori | 0.5 × MICori | 1 × MICori | 2 × MICori | 4 × MICori | 8 × MICori | 16 × MICori | 32 × MICori | 64 × MICori | 128 × MICori | 256 × MICori | 512 × MICori | 1024 × MICori | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cli1 | WTcla | – | – | – | A2143G | – | – | – | G2143A A2142G |
– | – | ||
| Cli2 | WTcla | – | A2142G | – | – | – | – | – | – | – | – | ||
| Cli3 | WTcla | – | – | A2143G | – | – | – | – | G2143A A2142G |
– | – | – | |
| Cli4 | WTcla | – | failure | ||||||||||
| Cli5 | WTcla | – | – | – | A2143G | – | – | – | – | – | – | – | – |
| Cli6 | WTcla | – | A2142C | – | – | – | – | – | – | – | – | – | – |
| Cli7 | WTcla | – | A2143G | – | – | – | – | – | – | – | – | – | – |
| Cli1 | WTlev | – | 87N, D91N |
– | – | – | – | – | N87K, 91N |
– | |||
| Cli2 | WTlev | 87N, D91G |
– | – | N87K, G91D |
87K, D91G |
– | – | – | ||||
| Cli3 | WTlev | – | – | 87N, D91N |
N87K, N91D |
– | 87K, D91N |
– | – | – | – | ||
| Cli4 | WTlev | – | 87N, D91G |
87N, G91Y |
– | – | – | – | – | – | |||
| Cli5 | WTlev | – | – | N87K, 91D |
– | 87K, D91G |
– | – | |||||
| Cli6 | WTlev | – | 87N, D91G |
– | – | – | – | N87K, 91G |
– | ||||
| Cli7 | WTlev | – | 87N, D91G |
– | N87K, 91G |
– | – | – | – | – | |||
| Cli1 | WTmet | – | S29F S43F T58I |
– | – | 26FS | – | V14L I26L |
– | ||||
| Cli2 | WTmet | – | 65FS | – | T68S T79S87 |
– | – | – | – | ||||
| Cli3 | WTmet | – | E133K I172N |
E75K E138K |
N172I | K75E K133E K138E |
– | – | – | ||||
| Cli4 | WTmet | – | – | – | – | – | – | – | – | ||||
| Cli5 | WTmet | – | – | – | – | E133K | |||||||
| Cli6 | WTmet | – | – | – | R16C | – | – | – | C16H E73G N98S A118S S150G |
– | |||
| Cli7 | WTmet | – | – | N64K E74G |
H17Y P51T G74E |
– | – | – | – | – |
Profile of 23S rRNA/gyrA amino acid/rdxA amino acid mutations during the process of antibiotics-induced resistance.
–, same as the former genotype; MICori, the original MIC for clinical strain; WTcla, wild-type genotype for 23Sr RNA; WTlev, wild-type genotype for gyrA; WTmet, wild-type genotype for rdxA.