Figure 1.

Risk scores constructed using m⁶A RNA methylation regulators. (a) Partial likelihood deviance determined by LASSO–Cox regression of OS rates among patients in the training cohort (n = 147). Dashed vertical line indicates logLambda = −3.55 (minimum partial likelihood deviance). (b, c) LASSO–Cox coefficients of 7 selected m⁶A regulators in the following model: risk score = FTO × 0.127 + YTHDF1 × 0.004 + KIAA1429 × 0.044 + YTHDC2 × 0.112 − RBM15 × 0.135 − ALKBH5 × 0.019 − YTHDF2 × 0.028. (d, e) Kaplan–Meier curves for OS rates among patients in the training cohort (d) and testing cohort (n = 146) (e). Patients in both cohorts were assigned to low- and high-risk categories based on a risk score cut-off value. (f, g) ROC curves indicated adequate predictive ability of the m⁶A risk score for the training (F) and testing (g) cohorts. m⁶A, N⁶-methyladenosine; OS, overall survival; ROC, receiver operating characteristic.