Table 1.
Top 20 most commonly reported adverse events reported with spironolactone in the U.S. Food and Drug Administration Adverse Event Reporting System database from January 1, 1969 to December 30, 2018.
| Category | n | % |
|---|---|---|
| Hyperkalemia | 1272 | 16.06 |
| Acute kidney injury | 1204 | 15.20 |
| Drug interaction | 710 | 8.96 |
| Hyponatremia | 665 | 8.40 |
| Dehydration | 483 | 6.10 |
| Hypotension | 398 | 5.03 |
| Fall | 377 | 4.76 |
| Nausea | 356 | 4.49 |
| Diarrhea | 346 | 4.37 |
| Dyspnea | 335 | 4.23 |
| Bradycardia | 321 | 4.05 |
| Dizziness | 321 | 4.05 |
| Renal Failure | 317 | 4.00 |
| Blood creatinine increased | 311 | 3.93 |
| Malaise | 302 | 3.81 |
| Asthenia | 298 | 3.76 |
| Vomiting | 288 | 3.64 |
| Drug ineffective | 261 | 3.30 |
| Confusional state | 258 | 3.26 |
| Fatigue | 220 | 2.78 |