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. 2020 Sep 28;10:15826. doi: 10.1038/s41598-020-72869-9

Figure 2.

Figure 2

Dose–response kinase enzymatic activity assays on 35 kinases treated with GW296115 reveal its biochemical potency. (A) Heatmap of % kinase activity with 9-point dose response to GW296115, plotted in descending order of IC50 values from Eurofins screen (N = 2). (B–G) Dose response curves for IDG kinases with IC50 < 100 (N = 2): DRAK2 (IC50 = 5.5 nM), BRSK2 (IC50 = 8.4 nM), PHKG1 (IC50 = 20 nM), BRSK1 (IC50 = 21 nM), DRAK1 (IC50 = 28 nM), and DCAMKL3 (IC50 = 89 nM), respectively. Python version 3.8 was used to make heatmap in (A).