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. 2020 Sep 28;10:15873. doi: 10.1038/s41598-020-71948-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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FADS locus genetic variation associations with lipid metabolites. Heatmaps depicting the significance (− log₁₀[p value]) and effect direction for associations between 52 metabolites and chromosome 11 SNPs in the FADS locus (± 100 kb) that reached a significance threshold (p < 1.2 × 10^–8). The effect direction and significance of association between the alternative (alt) allele and the metabolite levels are depicted by color (see color key). Green color indicates significantly higher metabolite levels associated with increasing numbers of the SNP alt allele. In contrast, red depicts lower metabolite levels associated with increasing numbers of the alt allele. The neutral beige color indicates associations p ≥ 1.2 × 10^–8. The heatmaps are separated by four major lipid classes including from top to bottom: (A) PL (31 metabolites), (B) lyso-PL (15 metabolites), (C) free fatty acid (5 metabolites), and (D) endocannabinoid (1 metabolite). The LD plot represents R² values using the CEU population from the 1,000 Genomes Project.