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. 2020 Sep 28;10:15873. doi: 10.1038/s41598-020-71948-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of FADS Gene* Dietary PUFA Interaction on energy homeostasis, innate immunity and brain development, memory, and cognitive function. This figure illustrates how levels of PUFAs in western diets^20,57 interact with global variation within the FADS locus to impact levels of LC-PUFA-containing lysophospholipids (lyso-PL), phospholipids (PL), unesterified fatty acids, and endocannabinoids. In turn, circulating and tissue levels of these lipid molecular species impact energy homeostasis⁵⁸, innate immunity⁵⁹, and brain PL composition, development, and function, potentially impacting a wide variety of human diseases⁶⁰.