Table 1.
Association between IL1RL1 rs11123923, MyD88 rs6853 and TIRAP rs8177374 polymorphic sites and H. pylori infection.
| Genes | Status | Number of individuals in each genotype | Total | HWE (P) | Allelic frequency | OR (CI)a | P value | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Co | Ra | |||||||||
| AA | AC | CC | ||||||||
| IL1RL1 | Cases | 138 | 258 | 102 | 498 | 0.86 (0.35) | 0.54 | 0.46 |
AA vs AC 0.59 (0.46–0.77) |
1.2 × 10–4 |
| Controls | 297 | 333 | 72 | 702 | 2.31 (0.12) | 0.66 | 0.34 | |||
| AA | AG | GG | ||||||||
| MyD88 | Cases | 312 | 186 | 0 | 498 | 26.26 (3 × 10–7) | 0.81 | 0.19 |
AG vs AA 0.98 (0.77–1.25) |
0.95 |
| Controls | 421 | 254 | 27 | 702 | 2.24 (0.13) | 0.78 | 0.22 | |||
| CC | CT | TT | ||||||||
| TIRAP | Cases | 421 | 77 | 0 | 498 | 3.5 (0.061) | 0.92 | 0.08 |
CT vs CC 0.50 (0.37–0.67) |
3.7 × 10–6 |
| Controls | 508 | 184 | 10 | 702 | 2.15 (0.14) | 0.85 | 0.15 | |||
Co common allele (IL1RL1: A; MyD88: A; TIRAP: C), Ra rare allele (IL1RL1: C; MyD88: G; TIRAP: T). a CI (confidence intervals) and P values were calculated with the Fisher’s exact test.