Table 2.

Cross-sectional HIV-1C analysis: correlates of viral co-receptor tropism.

Variable	Summary estimates
	Mean (standard deviation)		p-value	aOR [95% CI]
	CCR5-tropic (FPR > 3.5)	CXCR4-tropic (FPR ≤ 3.5)
Markers of immune activation
CD4+ T cell count (cells/µl)a	199 (225)	126 (216)	0.02	0.89 [0.80–0.99]
CD8+ T cell count (10log cells/µl)a	119 (156)	158 (105)	0.11	NA
CD38+ (% in CD4+ T cells)	58.5 (17.4)	62.0 (14.7)	0.87	NA
HLA-DR+ (% in CD4+ T cells)a	14.4 (14.6)	26.6 (25.4)	0.01	1.12 [0.91–1.36]
HLA-DR+ CD38+ (% in CD4+ T cells)a	7.3 (6.1)	12.0 (16.8)	0.03	0.99 [0.79–1.22]
CD70 (% in CD4+ T cells)a	1.1 (2.1)	2.0 (6.0)	0.08	0.98 [0.86–1.11]
HLA-DR+CD38+ (% in CD8+ T cells)a	22.7 (13.3)	15.6 (14.7)	0.52	NA
CD57+ (% in CD4+ T cells)	45.6 (16.7)	39.3 (14.3)	0.41	NA
CD169 (% in classical monocytes)	93.0 (35.5)	96.6 (20.1)	0.05	0.97 [0.84–1.11]
Central memory T cell (% of CD4+ T cells)	27.8 (13.4)	26.6 (10.0)	0.95	NA
TNFR2 (pg/ml)a	1,931 (1,226)	1,806 (809)	0.24	NA
sCD163 (pg/ml)a	383.4 (7,527.7)	34.6 (1,924.2)	0.49	NA
Receptor-ligand interactions
CCR5+ CXCR4+ (% in CD4+ T cells)a	5.5 (17.8)	6.4 (34.6)	0.20	NA
CCL3 (MIP-1⍺) (pg/ml)a	103.9 (116.1)	103.6 (72.6)	0.91	NA
CCL4 (MIP-1β) (pg/ml)a	57.3 (45.4)	65.1 (37.0)	0.95	NA
CCL5 (RANTES) (pg/ml)a	30,445 (95,015)	35,019 (179,839)	0.17	NA
CXCL12 (SDF-1⍺) (pg/ml)a	35.5 (824.8)	88.7 (2,014.2)	0.82	NA
CXCL10 (IP-10) (pg/ml)a	510.3 (816.3)	556.3 (259.1)	0.68	NA
IL-7 (pg/ml)a	117.3 (52.7)	106.9 (91.7)	0.92	NA

Units are displayed in italics.

aOR adjusted odds ratio, FPR false-positive rate, 95% CI 95% confidence interval.

P-values below 0.05 are displayed in bold.

^aData was log-transformed, means are log-corrected, standard deviation is original. p-value derived from unpaired t-test of (log-transformed) data.