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Risk stratification of smoldering multiple myeloma (SMM).
| High-risk SMM |
| Any 2–3 of the following high-risk factors: |
| Serum monoclonal protein >2 gm/dL |
| Serum free light-chain ratio (involved/uninvolved) >20 |
| Bone marrow plasma cells >20% |
| Intermediate-risk SMM |
| Any 1 high-risk factor |
| Low-risk SMM |
| No high-risk factor |
