Table 2.
HR of hepatobiliary and pancreatic cancer in the gallstone and cholecystectomy group
| Variable | Lag period (yr) |
PY | Hepatobiliary and pancreatic cancer | Liver cancer | Biliary tract cancer | Pancreatic cancer | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Event | HRa (95% CI) | Event | HRa (95% CI) | Event | HRb (95% CI) | Event | HRc (95% CI) | ||||||
| Gallstone | |||||||||||||
| No lag period | 76,200 | 487 | 2.16 (1.92-2.42) | 287 | 2.21 (1.92-2.53) | 133 | 2.97 (2.30-3.84) | 67 | 1.54 (1.13-2.10) | ||||
| 1 year of lag | 61,232 | 262 | 1.82 (1.59-2.08) | 184 | 1.96 (1.67-2.30) | 44 | 2.18 (1.57-3.01) | 34 | 1.23 (0.84-1.80) | ||||
| 3 year of lag | 37,102 | 144 | 1.52 (1.27-1.82) | 103 | 1.63 (1.32-2.02) | 24 | 1.79 (1.15-2.79) | 17 | 1.08 (0.65-1.80) | ||||
| 5 year of lag | 19,879 | 73 | 1.31 (1.02-1.68) | 52 | 1.45 (1.08-1.94) | 12 | 1.27 (0.63-2.55) | 9 | 1.03 (0.51-2.07) | ||||
| Cholecystectomy | |||||||||||||
| No lag period | 42,843 | 189 | 2.03 (1.72-2.39) | 87 | 1.59 (1.26-2.01) | 58 | 3.02 (2.15-4.25) | 44 | 2.78 (2.03-3.83) | ||||
| 1 year of lag | 34,156 | 113 | 1.76 (1.45-2.14) | 61 | 1.55 (1.20-2.01) | 19 | 1.93 (1.21-3.08) | 33 | 2.44 (1.68-3.55) | ||||
| 3 year of lag | 20,296 | 61 | 1.40 (1.07-1.84) | 36 | 1.23 (0.86-1.78) | 9 | 1.20 (0.57-2.51) | 16 | 2.24 (1.37-3.66) | ||||
| 5 year of lag | 10,618 | 31 | 1.25 (0.85-1.83) | 14 | 1.06 (0.63-1.79) | 5 | 1.24 (0.46-3.30) | 12 | 2.03 (1.01-4.06) | ||||
HR, hazard ratio; PY, person year. aAdjusted sex, diabetes, viral hepatitis, cirrhosis, fatty liver disease. bAjusted sex, liver cirrhosis. cAdjusted sex, diabetes, liver cirrhosis.