Table 3.
HR of hepatobiliary and pancreatic cancer’s subsite in the gallstone and cholecystectomy group
| Variable | Lag period (yr) |
PY | Intrahepatic bile duct cancer |
Gallbladder cancer | Extrahepatic bile duct cancer |
Ampulla of Vater cancer | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Event | HRa (95% CI) | Event | HRb (95% CI) | Event | HRc (95% CI) | Event | HRb (95% CI) | ||||||
| Gallstone | |||||||||||||
| No lag period | 76,200 | 41 | 2.32 (1.56-3.44) | 84 | 3.60 (2.54-5.09) | 32 | 2.81 (1.75-4.53) | 7 | 1.81 (0.67-4.91) | ||||
| 1 year of lag | 61,232 | 25 | 2.49 (1.64-3.78) | 25 | 2.79 (1.82-4.27) | 11 | 1.86 (0.99-3.50) | 3 | 1.66 (0.53-5.21) | ||||
| 3 year of lag | 37,102 | 11 | 1.84 (1.01-3.34) | 13 | 1.97 (1.06-3.69) | 6 | 1.46 (0.60-3.53) | 3 | 2.67 (0.85-8.40) | ||||
| 5 year of lag | 19,879 | 9 | 2.67 (0.98-4.17) | 5 | 1.06 (0.34-3.29) | 3 | 1.03 (0.26-4.14) | 2 | 1.59 (0.22-11.38) | ||||
| Cholecystectomy | |||||||||||||
| No lag period | 42,843 | 16 | 2.68 (1.63-4.40) | 30 | 2.07 (1.14-3.75) | 14 | 2.66 (1.44-4.89) | 5 | 4.25 (0.74-10.40) | ||||
| 1 year of lag | 34,156 | 15 | 2.86 (1.68-4.85) | 7 | 1.60 (0.76-3.347) | 6 | 1.41 (0.58-3.44) | 4 | 4.16 (0.54-11.24) | ||||
| 3 year of lag | 20,296 | 11 | 2.92 (1.51-5.64) | 1 | 0.36 (0.05-2.57) | 4 | 1.30 (0.41-5.90) | 2 | 3.33 (0.83-13.45) | ||||
| 5 year of lag | 10,618 | 7 | 4.08 (1.94-8.61) | 0 | - | 3 | 1.46 (0.36-5.90) | 1 | 3.02 (0.42-21.59) | ||||
HR, hazard ratio; PY, person year. aAdjusted sex, fatty liver disease. bAdjusted sex, diabetes. cAjusted sex, cirrhosis.