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. 2020 Sep 28;17:284. doi: 10.1186/s12974-020-01943-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Viral burdens in brains after intracranial infection with 93/783 and Torö. Six- to 10-week-old mice were infected intracranially with 10² FFU of 93/783 or Torö. Viral burdens in the olfactory bulb (a), cerebrum (b), cerebellum (c), and brainstem (d) were determined by qPCR; expression levels were normalized to the endogenous GAPDH expression and calculated using the ΔΔCT method. CXCL10 and TNFα expression levels were detected with qPCR in the olfactory bulb (e, i), cerebrum (f, j), cerebellum (g, h), and brainstem (h, l), normalized to GAPDH and expression levels in Torö day 1 for the different brain regions (N = 3 − 5). Asterisks indicate statistical significance calculated using Mann-Whitney test (ns = not significant, *P < 0.05, **P < 0.01)