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. 2020 Sep 28;17:284. doi: 10.1186/s12974-020-01943-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Sequence alignment. Structure of the E protein tries to explain the differences in neutralizing ability between the two vaccines. a Sequence alignment of the two vaccine TBEV strains Neudörfl (FSME-IMMUN®, reference) and K23 (Encepur®) with 93/783 and Torö using BioEdit software. b Two asymmetric units of the TBEV virion. Proposed antibody interacting sites [42] marked in grey and amino acids variations within the sites highlighted in pink. Magnification of neutralizing antibody interacting site close to the 3-fold symmetry axis (c) with the amino acid N52, K136, and I167 shown in pink, and the 5-fold symmetry axis (d) with the amino acid A83 shown in pink. PDB accession number 5O6A. Molecular graphics and structure editing were prepared using UCSF Chimera (https://www.cgl.ucsf.edu/chimera/) and PyMol (https://pymol.org/2/). e Anti-TBEV IgG ELISA of sera from individuals vaccinated with either FSME-IMMUN® (no. 11), Encepur® (no. 12) or a combination of both vaccines (no. 13), threshold set to < 0.213 dotted line. Neutralizing antibody titers against 93/783, Torö, and Neudörfl from individuals vaccinated with either FSME-IMMUN® (f), Encepur® (g), or a combination of both vaccines (h). Dotted line indicates threshold for neutralizing antibody titers. i Comparison of neutralizing antibody titers against 93/783 and Torö in vaccinated individuals with the different vaccines. Statistical significance was calculated using Friedman test (f, h) and Kruskal-Wallis multiple comparison test (i)