Table 2.

Incidence of Covid-19 with hydroxychloroquine as pre-exposure prophylaxis

Outcome	Placebo		Hydroxychloroquine once weekly			Hydroxychloroquine twice weekly
	No. of infections (%)	Event rate per person-yr (95% CI)	No. of infections (%)	Event rate per person-yr (95% CI)	Hazard Ratio (95% CI)	No. of infections (%)	Event rate per person-yr (95% CI)	Hazard Ratio (95% CI)
PCR positive or probable Covid-19	39 (7.9%)	0.38 (0.26 to 0.50)	29 (5.9%)	0.27 (0.17 to 0.37)	0.72 (0.44 to 1.16)	29 (5.9%)	0.28 (0.18 to 0.38)	0.74 (0.46 to 1.19)
PCR confirmed Covid-19	6 (1.2%)	0.06 (0.01 to 0.10)	4 (0.8%)	0.04 (0.00 to 0.07)	0.65 (0.18 to 2.32)	7 (1.4%)	0.07 (0.02 to 0.12)	1.18 (0.40 to 3.51)
Covid-19 compatible with symptoms	38 (7.7%)	0.38 (0.26 to 0.49)	29 (5.9%)	0.28 (0.18 to 0.38)	0.73 (0.45 to 1.19)	28 (5.7%)	0.28 (0.17 to 0.38)	0.74 (0.45 to 1.20)