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Expression of genes known to promote glomerular and tubulointerstitial damage are significantly reduced in RNA from LOXL2i-treated Alport mice relative to vehicle-treated Alport mice. RNA from either cortex (panel A) or isolated glomeruli (panel B) were analyzed by real time RT-PCR for the indicated transcripts. Statistically significant differences when comparing Alport-vehicle samples with the other cohorts are indicated by asterisks. Mean ± SEM * p<0.05.
