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. Author manuscript; available in PMC: 2020 Sep 29.
Published in final edited form as: Kidney Int. 2018 May 16;94(2):303–314. doi: 10.1016/j.kint.2018.02.024

Figure 8.

Figure 8.

Treatment of Alport mice with LOXL2i greatly improves GBM architecture. Renal cortex from wild type mice (panel A), vehicle-treated Alport mice (panel C) or LOXL2i –treated Alport mice (panel E) were subjected to transmission electron microscopic analysis as described in the methods. The irregular thickening and thinning of the GBM characteristic of Alport mice (C) is ameliorated in Alport mice treated with LOXL2i (E). Panels B, D, and F are wild type (B), vehicle-treated Alport (D) and LOXL2i-treated Alport (F) stained with anti α1(IV) collagen antibodies provided as a frame of reference. Glomerular capillaries are labeled with asterisks. Quantitative morphometric analysis for GBM thickness (Panel G) shows near complete normalization of GBM thickness in the LOXL2i-treated Alport mice. Mean ± SEM * p<0.05.