Table 1.
SNPs demonstrating genome-wide suggestive evidence of association in the African Ancestry OncoArray Analysis and comparison with results of OCAC studies of women of European ancestry
| Subtype | Nearest gene | SNP ID (effect/other allele) | Build 37 Chr:Pos | African ancestry2 | European ancestry3 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| EAF | OR (95% CI) | p Value | BFDP4 | EAF | OR (95% CI) | p Value | ||||
| EOC | AKR1C3 | rs4525119 (T/C) | 10:5091954 | 0.331 | 0.70 (0.61–0.81) | 4.9 × 10−7 | 8% | 0.300 | 1.00 (0.97–1.03) | 0.936 |
| LOC101927394 | TS76434591 (T/G) | 3:8004828 | 0.362 | 1.40 (1.22–1.60) | 8.4 × 10−7 | 5% | 0.421 | 1.00 (0.98–1.03) | 0.742 | |
| UGT2A2 | rs4286604 (A/G) | 4:70442165 | 0.268 | 0.69 (0.59–0.80) | 8.5 × 10−7 | 5% | 0.227 | 1.01 (0.98–1.05) | 0.421 | |
| WWC1 | rsl42091544 (T/C) | 5:167714000 | 0.034 | 3.22 (2.02–5.13) | 9.4 × 10−7 | 9% | 0.010 | 0.97 (0.83–1.13) | 0.665 | |
| HGSOC | FST | rs37792 (G/A) | 5:52644647 | 0.342 | 0.65 (0.55–0.76) | 6.0 × 10−8 | <1% | 0.308 | 1.03 (0.99–1.06) | 0.110 |
| MAGEC1 | rs57403204 (G/A) | X:141078552 | 0.064 | 2.62 (1.83–3.76) | 1.7 × 10−7 | 1% | 0.013 | 1.03 (0.90–1.18) | 0.682 | |
| LOCW5376360 | rs79079890 (G/T) | 10:3684148 | 0.032 | 3.20 (2.05–4.99) | 3.0 × 10−7 | 3% | 0.131 | 1.02 (0.98–1.08) | 0.534 | |
| PRPSAP1 | rs66459581 (A/AC) | 17:74355264 | 0.234 | 1.63 (1.35–1.97) | 5.1 × 10−7 | 2% | 0.089 | 0.97 (0.92–1.03) | 0.377 | |
| GABRG3 | rsll6046250 (G/T) | 15:27231950 | 0.046 | 2.95 (1.92–4.54) | 8.7 × 10−7 | 7% | – | – | – | |
| LQC105377300/GK2 | rsl92876988 (C/T) | 4:80297251 | 0.046 | 3.01 (1.94–4.68) | 9.2 × 10−7 | 8% | 0.014 | 0.75 (0.62–0.90) | 0.002 | |
We show the strongest associated SNP for each locus reaching p < 1 × 10−6 for each subtype.
Genotyped SNPs, if not indicated otherwise then imputed.
African ancestry was defined as >50% African ancestry as calculated by FastPop.
European ancestry was defined by self-report.
Bayesian false discovery probability (BFDP) assuming a prior of 1:1,000 among women of African ancestry.
Abbreviations: CI, confidence interval; EAF, effect allele frequency; EOC, epithelial ovarian cancer; HGSOC, high-grade serous ovarian carcinoma; OR, odds ratio; SNP, single nucleotide polymorphism.