Table 4.

Multivariable analysis of survival in women with uterine adenosarcoma by systematic review (n = 230).

		Progression-free survival					Cause-specific survival
		Survival	Univariable		Multivariable		Survival	Univariable		Multivariable
Characteristic	No	2-yr (%)	HR (95%CI)	P-value	HR (95%CI)	P-value	2-yr (%)	HR (95%CI)	P-value	HR (95%CI)	P-value
Lymph node metastasis				<0.001					<0.001
No	122	79.6	1		1		86.2	1		1
Yes	9	0	20.0 (7.83–51.1)		4.72 (0.92–24.2)	0.06	0	27.0 (10.0–72.7)		6.24 (1.17–33.4)	0.03
Sarcomatous overgrowth				<0.001					<0.001
No	68	79.4	1		1		92.9	1		1
Yes	92	46.8	3.39 (2.07–5.55)		2.88 (0.99–8.40)	0.053	63.2	5.95 (2.93–12.1)		3.02 (0.70–13.1)	0.14
Heterologous elements				<0.001					<0.001
No	119	90.2	1		1		96.1	1		1
Yes	35	36.8	4.95 (2.74–8.92)		2.08 (0.70–6.12)	0.19	42.0	7.88 (3.97–15.6)		3.63 (0.90–14.6)	0.07
Myometrial invasion				<0.001					<0.001
≤50%	139	82.4	1		1		87.2	1		1
>50%	21	36.1	3.07 (1.60–5.88)		1.51 (0.48–4.72)	0.48	50.5	4.27 (2.08–8.76)		1.62 (0.47–5.58)	0.44

A Cox proportional hazard regression model for multivariable analysis adjusted for collected covariates. Significant P-values are emboldened. Abbreviations: 2-yr, 2-year proportion.