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N234A and N165A mutations of the spike reduce binding to ACE2. (A) Representative biolayer interferometry sensorgrams showing binding of ACE2 to spike variants. (B) Binding responses for biolayer interferometry measurements of ACE2 binding to spike variants. Data are shown as mean ± standard deviation from three independent experiments for each variant. Asterisks represent statistical significance (Student’s t test; *0.01 < p < 0.05, **0.001 > p > 0.01, ***0.0001 < p < 0.001).
