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. 2020 Sep 15;8:570490. doi: 10.3389/fbioe.2020.570490

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Copyright © 2020 Peng, Lai, Chu, Hsieh, Tseng, Chiu and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Confocal images of prostate cancer cells showing cellular distribution of the NP preparations. (A) Treatment with only R6G-FU/FA-HA/Cy5-PG–c–PLGA NPs or Cy5-epigallocatechin gallate (EGCG)-loaded R6G-FU/FA-HA/PG–c–PLGA NPs vs. Cy5-EGCG. (B) Three-dimensional analysis of fluorescent PC3 cells adhered to Matrigel-coated microcarriers incubated with fluorescent Cy5-EGCG-loaded R6G-FU/FA-HA/PG–c–PLGA NPs.