Table II.
Biochemical indicators of ketamine in blood and urine of mice in the different experimental groups.
| A, 4 weeks | ||||||
|---|---|---|---|---|---|---|
| C (NS) | LK (30 mg/kg) | HK (60 mg/kg) | ||||
| Indicator | Aldh2-(n=15) | Aldh2+(n=15) | Aldh2-(n=15) | Aldh2+(n=15) | Aldh2-(n=15) | Aldh2+(n=15) |
| Serum Ket (ng/ml) | ND | ND | ND | ND | ND | ND |
| Serum Nket (ng/ml) | ND | ND | ND | ND | ND | ND |
| Urine Ket (ng/ml) | ND | ND | 868±95.9 | 896±94.3 | 1068±98.6 | 1,123±95.3 |
| Urine Nket (ng/ml) | ND | ND | 2,2681±734.2 | 2,0248±870.4 | 23,425±726.9 | 24,786±102.3 |
| B, 8 weeks | ||||||
| C (NS) | LK (30 mg/kg) | HK (60 mg/kg) | ||||
| Indicator | Aldh2-(n=15) | Aldh2+(n=15) | Aldh2-(n=15) | Aldh2+(n=15) | Aldh2-(n=15) | Aldh2+(n=15) |
| Serum Nket (ng/ml) | ND | ND | ND | ND | ND | ND |
| Urine Ket (ng/ml) | ND | ND | 1,076±103.2 | 998±87.3 | 1,324±112.3 | 1,238±109.3 |
| Urine Nket (ng/ml) | ND | ND | 24,564±924.3 | 23,652±898.3 | 27,347±923.4 | 25,863±954.2 |
| C, 12 weeks | ||||||
| C (NS) | LK (30 mg/kg) | HK (60 mg/kg) | ||||
| Indicator | Aldh2-(n=15) | Aldh2+(n=15) | Aldh2-(n=15) | Aldh2+(n=15) | Aldh2-(n=15) | Aldh2+(n=15) |
| Serum Nket (ng/ml) | ND | ND | 1.2±0.32 | 2.3±0.26 | 4.6±0.67 | 3.2±0.34 |
| Urine Ket (ng/ml) | ND | ND | 1,545±162.7 | 1,432±93.3 | 1,636±156.8 | 1,523±196.2 |
| Urine Nket (ng/ml) | ND | ND | 23,691±1,423.3 | 26,538±1,397.2 | 28,877±1,452.3 | 29,376±1,254.8 |
Data are presented as the mean ± standard error of the mean. Ket, ketamine; nket, norketamine; KO, knock-out; WT, wild-type; -, KO; +, WT; C, control; NS, normal saline; LK, low-dose ketamine; HK, high-dose ketamine; Aldh2, aldehyde dehydrogenase 2; Ket, ketamine; Nket, norketamine; ND, not detected.