Table 3.

Summary of phenotype associations from all-cohort meta-analysis for Validated CpGs. Bold entries highlight nominally significant associations (P < 0.05). *Significant after stringent multiple test correction

All cohorts	Meta direction	Expected direction of phenotype association	Prevalent CHD			Prevalent CVD			Incident CHD			Incident CVD			Mortality
			Beta	Std. Error	P value	Beta	Std. Error	P value	Beta	Std. Error	P value	Beta	Std. Error	P value	Beta	Std. Error	P value
cg21051031	Positive	Negative	−0.56	1.95	7.74E−01	−0.67	1.88	7.23E−01	0.96	1.80	5.94E−01	−0.28	1.41	8.43E−01	−0.79	0.81	3.31E−01
cg26094004	Negative	Positive	2.91	1.48	4.89E−02	3.13	1.40	2.55E−02	0.89	0.93	3.39E−01	−0.13	0.77	8.63E−01	−0.78	0.49	1.16E−01
cg26563141	Negative	Positive	0.22	1.33	8.69E−01	−0.31	1.24	8.00E−01	0.13	0.94	8.88E−01	1.10	0.75	1.40E−01	0.98	0.45	2.87E−02
cg14575356	Positive	Negative	−1.80	2.04	3.79E−01	−2.19	1.88	2.45E−01	2.71	1.34	4.36E−02	1.75	1.08	1.04E−01	0.12	0.68	8.63E−01
cg23513930	Positive	Negative	1.99	3.37	5.54E−01	0.88	3.07	7.75E−01	2.24	1.84	2.24E−01	0.50	1.49	7.39E−01	1.07	0.94	2.53E−01
cg08899667	Negative	Positive	3.65	1.76	3.81E−02	3.35	1.61	3.81E−02	1.57	1.10	1.54E−01	0.06	0.93	9.44E−01	2.08	0.59	3.93E−04*