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. 2020 Sep 28;12:83. doi: 10.1186/s13073-020-00780-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Synergistic therapeutic effect of SB-3CT treatment combined with CTLA-4 blockade. Tumor volumes of a B16F10 or b LLC tumor-bearing C57/BL6 mice treated with isotype, SB-3CT, anti-CTLA-4, or combination strategy. Kaplan–Meier survival analysis of c B16F10 or d LLC tumor-bearing C57/BL6 mice treated with isotype, SB-3CT, anti-CTLA-4, or combination strategy. e–i Immune features in B16F10 tumor-bearing C57/BL6 mice treated with isotype, SB-3CT, anti-CTLA-4, or combination strategy. e Fluorescence expression and f quantification of PD-L1 expression in tumor. g Fluorescence expression and h quantification of PD1⁺CD8⁺ T cells in tumor. i Heatmap represents Z-score normalized percentage of immune cell populations. Sample size per group in one experiment is 5. Error bars represent s.d. of individual mice per group in one experiment. NS, p > 0.05, *p < 0.05, **p < 0.01, and ***p < 0.001, as determined by a, b two-way ANOVA, c, d two-sided log-rank test, and f, h one-way ANOVA and Dunnett’s multiple comparison test