Table 1.

Blood collection plan

Sample (Blood)	Volume (mL)	Cycle	Day	Sample No.	Scheduled time relative to BEZ235 dosing post-dose (hours)
	3	1	1	1	Pre-dose
				2	1 h post-dose
	3	1	1	3	2 h post-dose
	3	1	1	4	3 h post-dose
				5	5 h post dose
	3	1	1	6	8–12 h post-dose
(optional)	3	1	2	7	24 h post-dose (trough)
	3	1	15	8	Pre-dose
	3	1	15	9	1 h post-dose
	3	1	15	10	3 h post-dose
	3	1	15	11	5 h post-dose
(optional)	3	1	15	12	8–12 h post-dose

Blood sample collection plan in the BEZ 235 phase I trial for PK and PD analysis is shown