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. 2020 Sep 29;18:139. doi: 10.1186/s12951-020-00694-3

Fig. 3.

Fig. 3

a Relative mRNA levels of chondrogenic markers (Acan, Col2a1) and OA-relative genes (Adamts5, COX2, Il6, iNos, Mmp1, Mmp3, Mmp13). Data was presented as the mean ± SD (n = 3). *, #p < 0.05; **, ##p < 0.01; ***, ###p < 0.001. b Safranin O stained for GAG production (scale bar: 200 µm). c The expression of MMP-13 was detected by immunofluorescent staining (scale bar: 100 µm)