. Author manuscript; available in PMC: 2020 Sep 29.

Published in final edited form as: Eur J Surg Oncol. 2019 Feb 18;45(8):1417–1424. doi: 10.1016/j.ejso.2019.02.019

Table 3.

Independent prognostic factors in pathological stage IIB cervical cancer.

Characteristics	Disease-free survival		Cause-specific survival
	Adjusted-HR (95%CI)	P-value	Adjusted-HR (95%CI)	P-value
Age (years)
≥50	1		1
<50	1.567 (1.125–2.181)	0.008	2.166 (1.454–3.224)	<0.001
Histology
SCC	1		1
Non-SCC	2.205 (1.587–3.064)	<0.001	2.139 (1.446–3.163)	<0.001
Pelvic lymph node		<0.001^a		<0.001^a
Not involved	1		1
Single metastasis	1.234 (0.720–2.113)	0.445	1.013 (0.482–2.128)	0.974
Multiple metastasis	2.535 (1.726–3.725)	<0.001	2.725 (1.686–4.404)	<0.001
Missing	-	-	-	-
Para-aortic lymph node		0.004^a		0.012^a
Not involved	1		1
Single metastasis	1.422 (0.654–3.090)	0.375	1.647 (0.690–3.932)	0.261
Multiple metastasis	2.428 (1.286–4.584)	0.006	2.466 (1.163–5.228)	0.019
Clinically not involved	0.909 (0.594–1.391)	0.660	0.913 (0.535–1.556)	0.737

Cox proportional hazard regression models for multivariate analysis (conditional backward). Only significant covariates (P < 0.05) in the final models were shown in the table.

P-value for interaction. – suppressed due to number <5. Abbreviations: HR, hazard ratio; CI, confidence interval; SCC, squamous cell carcinoma; Adeno, adenocarcinoma; AS, adenosquamous; DSI, deep stromal invasion; LVSI, lympho-vascular space invasion; RT, whole pelvic radiotherapy; CCRT, concurrent chemo-radiotherapy.