TABLE 1.
Contributing factors for patient declination of postoperative radiotherapy in stage I endometrioid endometrial cancer (N = 10 613)
| Characteristic | Declined RT | Received RT | Adjusted-ORa (95%CI) | P-value |
|---|---|---|---|---|
| Number (%) | 323 (3.0%) | 10 290 (97.0%) | ||
| Age (y) | 70.8 (±11.5) | 65.8 (±10.5) | ||
| <60 | 61 (2.1%) | 2798 (97.9%) | 1 | |
| ≥60 | 262 (3.4%) | 7492 (96.6%) | 1.52 (1.13-2.04) | 0.005 |
| Ethnicity | ||||
| White | 273 (3.2%) | 8383 (96.8%) | 1.53 (1.12-2.10) | 0.01 |
| Non-White | 50 (2.6%) | 1907 (97.4%) | 1 | |
| Marital status | ||||
| Single | 42 (3.1%) | 1331 (96.9%) | 1.37 (0.95-1.96) | 0.09 |
| Married | 132 (2.4%) | 5397 (97.6%) | 1 | |
| Others | 149 (4.0%) | 3562 (96.0%) | 1.65 (1.30-2.11) | <0.001 |
| Registry area | ||||
| West | 231 (4.6%) | 4744 (95.4%) | 2.13 (1.59-2.86) | <0.001 |
| Central | 60 (2.4%) | 2453 (97.6%) | 1 | |
| East | 32 (1.0%) | 3093 (99.0%) | 0.40 (0.26-0.63) | <0.001 |
| Year at diagnosis | ||||
| Before 2000 | 79 (2.7%) | 2794 (97.3%) | 1 | |
| 2000 and after | 277 (3.2%) | 7496 (96.8%) | 1.40 (1.04-1.88) | 0.03 |
| Grade | ||||
| 1-2 | 175 (3.0%) | 5068 (97.0%) | 1 | |
| 3 | 148 (3.1%) | 4682 (96.9%) | 1.12 (0.84-1.49) | 0.43 |
| Stage | ||||
| IA | 76 (2.7%) | 2727 (97.3%) | 1 | |
| IB | 247 (3.2%) | 7563 (96.8%) | 1.10 (0.78-1.53) | 0.59 |
| Tumor size (cm) | ||||
| <2.0 | 19 (2.6%) | 713 (97.4%) | 1 | |
| ≥2.0 | 182 (3.1%) | 5604 (96.9%) | 1.13 (0.69-1.83) | 0.63 |
| Unknown | 122 (3.0%) | 3973 (97.0%) | 1.20 (0.73-1.96) | 0.48 |
| Surgery type | ||||
| Simple hyst | 273 (3.1%) | 8610 (96.9%) | 1 | |
| Others | 50 (2.9%) | 1680 (97.1%) | 0.98 (0.70-1.37) | 0.91 |
| Pelvic lymphadenectomy | ||||
| Performed | 224 (3.0%) | 7134 (97.0%) | 1 | |
| Not performed | 96 (3.2%) | 2895 (96.8%) | 0.95 (0.73-1.24) | 0.69 |
| Unknown | 3 (1.1%) | 261 (98.9%) | 0.34 (0.10-1.20) | 0.08 |
hyst, hysterectomy; OR, odds ratio; CI, confidence interval; and RT, radiotherapy. Number (%) per row or mean (±SD) is shown. A binary logistic regression model for multivariable analysis. All listed covariates were entered in the final model. Significant P-values are emboldened. Grade 3 cases included undifferentiated endometrioid type.
a
OR for patient declination for postoperative radiotherapy compared to postoperative radiotherapy.