Fig. 5.

Endothelial permeability abilities of AuNRBR/N. a Schematic diagram for measuring penetration efficiency of AuNRBR/N across an endothelial monolayer by using a transwell system. AuNRBR quantitatively determined in the supernatant (upper chamber), cell monolayer and filtrate (lower chamber). b The quantity of AuNRBR distributed in each compartment in the absence or presence of fMLP for 4 h. c In vivo tumor bearing mice fluorescence imaging at post-injection of 4, 8, 12, 24 and 48 h (left) and major organs and tumors taken out for further imaging at post-injection of 12 h (right). The error bars were presented as mean ± SD (n = 3). *p < 0.05, ***p < 0.001