Figure 8.

Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex

(A) Uniform allelic expression of imprinted genes in major forebrain cell types, including projection neurons, interneurons and astrocytes in CX and HC and olfactory granule cells.

(B) Imprinted genes show highly variable expression levels in distinct cortical cell types.

(C) UPD results in imbalanced imprinted gene expression, which in turn leads to highly cell-type-specific but global transcriptional changes.

(D) UPD results in highly cell-type-specific phenotypes, revealing a novel function for dosage-sensitive imprinted gene expression in cortical astrocyte development. The astrocytes with chr7 patUPD show a survival advantage compared with chr7 matUPD astrocytes.