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GBM organoids respond differentially based on cell line type. Organoids were comprised of a GBM cell line (red) and astrocytes (green) and nuclei (blue) imaged by macro-confocal microscopy in response to therapies. (A) U373-based organoids respond dramatically to erlotinib. (B) A172-based organoids, which have a p53 mutation, respond to a p53 activator compound to some degree. Scale bars: 250 μm.
