Figure 2.

PEG10 deletion inhibits cell growth, metastasis and enhances cell apoptosis in DLBCL. (A) The knockdown efficiency of PEG10 in DLBCL cells. (B, C) Detection of cell proliferation and apoptosis in SU-DHL-8 and OCI-LY-8 cells using MTT assay and low cytometry analysis, respectively. (D) The proliferation-related protein cyclinD1 and the apoptosis-related proteins Bcl-2, caspase-3 and Bax level in DLBCL cells were detected by western blot. (E) Transwell assays were used to evaluate the migratory and invasive abilities of DLBCL cells. * P<0.05. PEG10 – paternally expressed imprinted gene 10; DLBCL – diffuse large B-cell lymphoma.