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. 2020 Sep 24;26:e926651-1–e926651-12. doi: 10.12659/MSM.926651

Table 1.

Baseline characteristics and disease severity of all included COVID-19 patients complicated with hypertension.

Parameters Overall (n=210) ACEIs/ARBs (n=81) Non-ACEIs/ARBs (n=129) P value
Age (years), median (IQR) 67.00 (59.75–74.00) 68.00 (61.50–76.00) 66.00 (59.00–72.50) 0.107
Male sex, n (%) 100 (47.62) 38 (46.91) 62 (48.06) 0.871
BMI, median (IQR) 24.15 (21.97–26.03) 24.22 (22.01–26.36) 24.09 (21.87–25.39) 0.357
Vital signs on admission
 Body temperature (°C), median (IQR) 36.50 (36.28–36.70) 36.50 (36.20–36.70) 36.50 (36.30–36.70) 0.422
 SpO2 (%), median (IQR) 97.00 (96.00–98.00) 97.00 (96.00–98.00) 97.00 (96.00–98.00) 0.680
 SBP (mmHg), median (IQR) 140.00 (129.00–150.00) 144.00 (130.00–155.00) 140.00 (128.00–147.00) 0.022
 DBP (mmHg), median (IQR) 84.00 (75.00–94.00) 83.00 (76.50–93.00) 85.00 (75.00–94.00) 0.770
 HR, median (IQR) 85.00 (78.00–94.00) 82.00 (77.50–92.50) 87.00 (80.00–95.00) 0.213
 RR, median (IQR) 20.00 (18.00–20.00) 20.00 (18.00–20.00) 20.00 (18.00–20.00) 0.408
7-categorical ordinal scale on admission
 =3, n (%) 111 (52.86) 32 (39.51) 79 (61.24) 0.002
 >3, n (%) 99 (47.14) 49 (60.49) 50 (38.76) 0.002
 4 89 (42.38) 42 (51.85) 47 (36.43) 0.028
 5 10 (4.76) 7 (8.64) 3 (2.33) 0.079
Classification on admission
 Mild cases, n (%) 145 (69.05) 55 (67.90) 90 (69.77) 0.776
  Grade 1 6 (2.86) 2 (2.47) 4 (3.10) 1.000
  Grade 2 139 (66.19) 53 (65.43) 86 (66.67) 0.854
 Severe cases, n (%) 65 (30.95) 26 (32.10) 39 (30.23) 0.776
  Grade 3 52 (24.76) 19 (23.46) 33 (25.58) 0.728
  Grade 4 13 (6.19) 7 (8.64) 6 (4.65) 0.243
Other comorbidities, n (%) 136 (64.76) 62 (76.54) 74 (57.36) 0.005
 Diabetes 55 (26.19) 22 (27.16) 33 (25.58) 0.800
 Hyperlipidemia 14 (6.67) 6 (7.41) 8 (6.20) 0.733
 Cardiovascular diseases 61 (29.05) 27 (33.33) 34 (26.36) 0.278
 Chronic respiratory diseases 19 (9.05) 5 (6.17) 14 (10.85) 0.250
 Cerebral vascular diseases 24 (11.43) 9 (11.11) 15 (11.63) 0.909
 Chronic liver diseases 11 (5.24) 5 (6.17) 6 (4.65) 0.630
 Chronic renal diseases 8 (3.81) 2 (2.47) 6 (4.65) 0.664
 Benign tumors 1 (0.48) 60 (0) 1 (0.78) 1.000
Laboratory test on admission
 K+ (mmol/L), median (IQR) 4.11 (3.84–4.41) 4.10 (3.81–4.39) 4.11 (3.85–4.46) 0.404
 Na+ (mmol/L), median (IQR) 139.85 (138.18–141.33) 140.00 (138.25–141.50) 139.80 (138.05–141.35) 0.881
 Cl− (mmol/L), median (IQR) 104.40 (102.10–106.30) 104.00 (102.15–106.10) 104.70 (102.05–106.35) 0.575
 ALT (U/L), median (IQR) 20.72 (15.57–30.46) 21.09 (16.43–31.36) 20.35 (14.63–30.67) 0.537
 GGT (U/L), median (IQR) 27.85 (18.08–38.29) 27.38 (17.78–36.50) 28.38 (18.30–40.83) 0.754
 TBIL (μmol/L), median (IQR) 10.53 (8.79–13.32) 10.40 (8.94–13.34) 10.64 (8.32–13.30) 0.892
 DBIL (μmol/L), median (IQR) 2.30 (1.69–3.36) 2.46 (1.77–3.86) 2.21 (1.64–3.12) 0.091
 IBIL (μmol/L), median (IQR) 8.30 (6.41–10.26) 8.40 (6.41–10.20) 8.28 (6.35–10.38) 0.993
 CREA (μmol/L), median (IQR) 59.58 (48.88–73.71) 61.23 (51.35–76.45) 58.35 (47.76–71.28) 0.047
 Urea (mmol/L), median (IQR) 5.20 (4.25–6.17) 5.20 (4.34–6.28) 5.13 (4.18–6.12) 0.375
 UA (μmol/L), median (IQR) 302.12 (246.10–351.68) 310.00 (241.78–369.07) 296.40 (246.80–346.72) 0.291
 WBC (109/L), median (IQR) 6.06 (4.84–7.03) 5.95 (4.99–6.84) 6.11 (4.77–7.22) 0.671
 NEUT (109/L), median (IQR) 3.48 (2.74–4.50) 3.45 (2.79–4.44) 3.55 (2.70–4.55) 0.969
 LYMPH (109/L), median (IQR) 1.50 (1.14–1.99) 1.65 (1.05–1.99) 1.48 (1.20–2.01) 0.609
 MONO (109/L), median (IQR) 0.50 (0.40–0.64) 0.46 (0.40–0.59) 0.51 (0.40–0.66) 0.164
 CRP (mg/L), median (IQR) 0.62 (0.50–4.41) 0.73 (0.50–4.32) 0.56 (0.50–4.52) 0.613
 IL-6 (pg/ml), median (IQR) 2.68 (1.50–6.65) 2.56 (1.50–6.24) 2.78 (1.50–6.74) 0.533

ACEIs – angiotensin-converting enzyme inhibitors; ARBs – angiotensin II receptor blockers; IQR – interquartile range; BMI – body mass index; SpO2 – oxyhemoglobin saturation; SBP – systolic blood pressure; DBP – diastolic blood pressure; HR – heart rate; RR – respiratory rate; ALT – alanine aminotransferase; GGT – γ-glutamyl transpeptidase; TBIL – total bilirubin; DBIL – direct bilirubin; IBIL – indirect bilirubin; CREA – creatinine; UA – uric acid; WBC – white blood cells; NEUT – neutrophil; LYMPH – lymphocyte; MONO – monocyte; CRP – C-reactive protein; IL-6 – interleukin-6; SARS-CoV-2 – severe acute respiratory syndrome coronavirus 2.