Table 1.
Patients’ characteristics
| Total n (%) 135 Patients | CIRT Cohort n (%) 65 Patients | PT Cohort n (%) 70 Patients | P-value | |
|---|---|---|---|---|
| KPS | 0.8493 | |||
| ≤80 | 22 (16) | 11 (17) | 11 (16) | |
| 90–100 | 113 (84) | 54 (83) | 59 (84) | |
| Sex | 0.374 | |||
| Male | 82 (61) | 42 (65) | 40 (57) | |
| Female | 53 (39) | 23 (35) | 30 (43) | |
| Age, y, median (range) | 57 (13–81) | 58 (13–81) | 53 (17–81) | 0.1388 |
| Treatment | 0.019 | |||
| Primary | 107 (79) | 46 (71) | 61 (87) | |
| Recurrent | 28 (21) | 19 (29) | 9 (13) | |
| Aim of the treatment | 0.146 | |||
| Postoperative | 130 (96) | 61 (94) | 69 (99) | |
| Exclusive | 5 (4) | 4 (6) | 1 (1) | |
| Resection status | <0.0001 | |||
| Complete | 19 (14) | 0 (0) | 19 (27) | |
| Incomplete | 115 (85) | 64 (98) | 51 (73) | |
| Only biopsy | 1 (1) | 1 (2) | 0 (0) | |
| Surgical technique | 0.130 | |||
| Endoscopic endonasal | 112 (83) | 55 (84) | 57 (82) | |
| Other approach (transcranial) | 13 (10) | 5 (8) | 8 (11) | |
| Not known | 10 (7) | 5 (8) | 5 (7) | |
| Surgery (n) | 0.285 | |||
| 1 | 77 (57) | 34 (52) | 43 (61) | |
| >1 | 58 (43) | 31 (48) | 27 (39) | |
| Brainstem abutment and/or compression | 0.671 | |||
| Y | 31 (23) | 14 (22) | 17 (25) | |
| N | 103 (77) | 51 (78) | 52 (75) | |
| Not evaluated * | 1 | 0 (0) | 1 | |
| Optic pathway abutment and/or compression | 0.579 | |||
| Y | 11 (8) | 58 (89) | 64 (94) | |
| N | 123 (92) | 7 (11) | 4 (6) | |
| Not evaluated * | 1 | 0 (0) | 1 | |
| Visual defect | 0.016 | |||
| Y | 24 (18) | 17 (26) | 7 (10) | |
| N | 110 (81) | 48 (74) | 62 (89) | |
| Not evaluated | 1 (1) | 0 (0) | 1 (1) | |
| Diplopia | 0.5945 | |||
| Y | 55 (41) | 28 (43) | 27 (33) | |
| N | 80 (59) | 37 (57) | 47 (67) | |
| Hearing impairment | 0.5221 | |||
| Y | 62 (46) | 28 (43) | 34 (49) | |
| N | 73 (54) | 37 (57) | 36 (51) | |
| Pituitary dysfunction | 0.303 | |||
| N | 112 (82.9) | 51 (78.4) | 61 (87.1) | |
| Y (1 hormonal deficit) | 10 (7.4) | 7 (10.8) | 3 (4.3) | |
| Y (>1 hormonal deficits) | 13 (9.6) | 7 (10.8) | 6 (8.6) | |
| Cranial nerve deficit | 0.014 | |||
| Y | 58 (43) | 35 (54) | 23 (33) | |
| N | 77 (57) | 30 (46) | 47 (67) | |
| GTV, cm3, median (range) | 7 (0–99.3) | 13 (0.4–87.4) | 3.5 (0–99.3) | 0.0001 |
| Dose, median (range) | ‒ | 70.4 (70.4-70.4) | 74 (72–74) | ‒ |
Abbreviations: *Only CT imaging, CIRT: carbon ion radiotherapy, PT: proton therapy, Y: yes, N: no, GTV: gross target volume, KPS: Karnofsky performance status.