Fig. 3.

The abnormality index is significantly elevated in patients with IDH wildtype tumors. (A) The ABI of both the lesional hemisphere (indicated in gray, mean ABI ± 2 standard deviations) and the contralesional hemisphere (indicated in white, mean ABI ± 2 standard deviations) was significantly higher in IDH wildtype glioma patients than in IDH-mutated glioma patients (P < 0.05, respectively, two-tailed t-test). (B) The individual connectome map (z-score of voxelwise abnormality count) of a patient with an IDH wildtype, TERT-mutated glioma with bilateral severe abnormality (patient 19). (C) The connectome map of a patient with an IDH1-mutated grade II oligodendroglioma with connectivity changes largely confined to the tumor itself.