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. 2020 Sep 15;11:630. doi: 10.3389/fendo.2020.00630

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Copyright © 2020 Nigi, Brusco, Grieco, Licata, Krogvold, Marselli, Gysemans, Overbergh, Marchetti, Mathieu, Dahl Jørgensen, Sebastiani and Dotta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CXCL10 is expressed in ICIs and IDIs of new-onset diabetic individuals and distinguished four pancreatic islet subsets. Triple immunofluorescence analysis of insulin (INS, green), glucagon (GCG, blue), and CXCL10 (red) in pancreatic sections of new-onset T1D DiViD cases. Representative pancreatic islet 40 × confocal microscope images are shown for each channel, alongside with digital zoom-in for each set of panel. (A–E) ICI showing positivity for CXCL10. (F–J) ICI without CXCL10 positivity. (K–O) IDI showing CXCL10 positivity. (P–T) IDI without positivity for CXCL10. Scale bar =100 μm. Scale bar zoom-in = 40 μm.