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Screening of HCK as a regulator for the NLRP3 inflammasome. (A) Flowchart showing the candidate siRNA library targeting 31 putative tyrosine kinases in BMDM. IL-1β and TNF-α levels were determined. (B, C) Enzyme-linked immunosorbent assay (ELISA) for IL-1β (B) or TNF-α (C) in supernatants from LPS-primed (500 ng, 3 h) PMs transfected with control siRNA (scrambled) or siRNAs specific for the individual tyrosine kinases post-nigericin (5 μM) stimulation for 30 min.
