Figure 3.

Closed-loop system. The FlorenceD2A closed-loop system (University of Cambridge, Cambridge, UK) (125). Median sensor glucose (A) and insulin delivery (B) during closed-loop insulin delivery period (solid red line and red-shaped area) and sensor-augmented pump period (dashed black line and gray-shaped area) from midnight to midnight. The glucose range 3.9–10.0 mmol/L (70–180 mg/dL) is denoted by horizontal dashed lines (A).