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. 2020 Sep 15;8:1027. doi: 10.3389/fbioe.2020.01027

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Copyright © 2020 Li, Salzano, Qiu, Menard, Berg, Theodossiou, Ladavière and Gref.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Upper panel: Schematic representation of the MIL-100(Fe) nanoMOF assembly from iron trimers and trimesic acid. Gem-MP was loaded by impregnation from aqueous solutions, penetrating inside the nanoMOFs through their largest windows (approx. 9 Å in size). Lipid molecules (DOPC and DSPE-PEG 2000) with larger molecular dimensions than the large windows were used to coat the nanoMOFs. Lower panel: Preparation steps of lipid-coated nanoMOFs. First, Gem-MP was loaded, into the nanoMOFs followed by their coating with lipid shells and PEG-lipid conjugates.