FIGURE 2.

Divergence of the marginal HR (HRm) from a constant conditional HR (HRc) if susceptibility is continuous, by cumulative incidence and the variance of susceptibility (s), where s is normal with mean = 0, variance = v, in a hypothetical RCT where treatment doubles risk and time-to-event is proportional to exp(lnHRc × tx + sqrt(v) × s). These curves, shown here for HRc = 2, would be similar at any other non-null level of the HRc.