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. 2019 Nov 15;22(5):493–499. doi: 10.4103/aja.aja_122_19

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Copyright: ©The Author(s)(2019)

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PRPS2 depletion and hypospermatogenesis. (a) PRPS2 mRNA levels were increased with age in the testis. (b) PRPS2 protein level increased with age in the testis. (c) When treated with murine PRPS2-specific shRNA lentivirus, PRPS2 downregulation was observed in testis tissues at 9 weeks of age. (d) When treated with murine PRPS2-specific shRNA lentivirus, hypospermatogenesis was observed in the testis. Upper row: low-power magnification, scale bars=500 μm. Lower row: high-power magnification, scale bars=50 μm. Black arrow: damaged seminiferous tubules. PRPS2: phosphoribosyl-pyrophosphate synthetase 2; NC: negative control; W: weeks.