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. 2019 Nov 15;22(5):493–499. doi: 10.4103/aja.aja_122_19

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Copyright: ©The Author(s)(2019)

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

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The potential genes and pathways regulated by PRPS2 were identified in GC1 cells. (a) Scatter diagram of the differential genes in GC1/PRPS2 and GC1/NC cells. (b) Potential signaling pathways of the differential genes in GC1/PRPS2 and GC1/NC cells. (c) Scatter diagram of the differential genes in GC1/shPRPS2 and GC1/NC cells. (d) Potential signaling pathways of the differential genes in GC1/shPRPS2 and GC1/NC cells. (e) Nine genes associated with cell apoptosis signal were confirmed in GC1 cells by qRT-PCR. (f) Transcriptional activity of E2F1 was measured by Luciferase Reporter Assay. *GC1/NC versus GC1/PRPS2 and GC2/NC versus GC2/PRPS2, P < 0.05 by independent-samples t-test. PRPS2: phosphoribosyl-pyrophosphate synthetase 2; NC: negative control; qRT-PCR: quantitative real-time polymerase chain reaction; Polg: polymerase (DNA directed), gamma; E2F1: E2F transcription factor 1; Egr1: early growth response 1; BRE: brain and reproductive organ-expressed; PHLDA3: pleckstrin homology-like domain family A member 3; SRA1: steroid receptor RNA activator 1.