Supplementary Table 1.

The sense sequences of genes were as follow

Name	Sequece
PRPS2-F-Human	5’- AGCTCGCATCAGGACCTGT-3’
PRPS2-R-Human	5’- ACGCTTTCACCAATCTCCACG-3’
PRPS2-F-Mouse	5’- ATGCTGGAGGAGCCAAAAG-3’
PRPS2-R-Mouse	5’- ACATCACCCACGAGAACCAT-3’
SRA1-F-Mouse	5’- ACGACCCGCCACAATTCTC-3’
SRA1-R-Mouse	5’- CTGGAAGCCTTACTTGAAGGAG-3’
PHLDL3-F-Mouse	5’- CCGTGGAGTGCGTAGAGAG-3’
PHLDA3-R-Mouse	5’- TCTGGATGGCCTGTTGATTCT-3’
E2F1-F-Mouse	5’- CTCGACTCCTCGCAGATCG-3’
E2F1-R-Mouse	5’- GATCCAGCCTCCGTTTCACC-3’
BRE-F-Mouse	5’- GGTGGACTACGCGGAGAAC-3’
BRE-R-Mouse	5’- CACCTGACTCAACCGCTCTTT-3’
Sirt6-F-Mouse	5’- ATGTCGGTGAATTATGCAGCA-3’
Sirt6-R-Mouse	5’- GCTGGAGGACTGCCACATTA-3’
Egr1-F-Mouse	5’- TCGGCTCCTTTCCTCACTCA-3’
Egr1-R-Mouse	5’- CTCATAGGGTTGTTCGCTCGG-3’
Celsr2-F-Mouse	5’- CACGATGGCCTGAGGGTTT-3’
Celsr2-R-Mouse	CCTTGTGGAGAAAGGTGTCCT-3’
Polg-F-Mouse	5’- GAGCCTGCCTTACTTGGAGG-3’
Polg-R-Mouse	5’- GGCTGCACCAGGAATACCA-3’
Spata2l-F-Mouse	5’- ATGTGCTGAAGGGTGTACTCT-3’
Spata2l-R-Mouse	5’- GGGGTGGTCACCATTAGGC-3’
GAPDH-F-Human	5’- CTGAACGGGAAGCTCACTGG-3
GAPDH-R-Human	5’- TGAGGTCCACCACCCTGTTG-3’
GAPDH-F-Mouse	5’- AGGTCGGTGTGAACGGATTTG-3’