. 2020 Sep 28;40(20):e00341-20. doi: 10.1128/MCB.00341-20

TABLE 3.

Summary of mouse models used to study the tumor-suppressive role of KDM6A in different cancer types

Cancer type	Mouse model	Reference	Observed phenotype
Bladder	Kdm6a^flox; Upk2-Cre	53	Increased tumor burden and reduced survival rate
Bladder	Kdm6a^flox; Upk2-Cre	54	Increased cancer development and CD44-positive stem cell proliferation
Lung	Kdm6a^flox; Kras^G12D; Ad-Cre	55	Increased cancer progression and tumor burden. Shortened life span.
Pancreas	Kdm6a^flox; Kras^G12D; Pdx1-Cre	24	More aggressive tumor development. Shortened life span.
	Kdm6a^flox; Kras^G12D; Ptf1a-Cre
	Kdm6a^flox; Kras^G12D; Pdx1-Cre	20
Blood	Kdm6a^flox; Mx1-Cre	11	Higher chance to develop AML in female KO mice. Increased HSPC self-renewal and decreased HSPC differentiation.
	Kdm6a^flox; CD19-Cre	36	Accelerated Eμ-Myc-induced B cell lymphomagenesis
	Kdm6a^flox; CreER	57	Accelerated chromic myelomonocytic leukemia and shortened life span