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Persistent exposure to the CGRP receptor antagonist olcegepant has no effect on orofacial mechanical withdrawal thresholds in mice. In an additional cohort of mice that had to be terminated early (Day 7) due to the COVID-19 pandemic, repeated daily exposure of mice to sumatriptan [F(2,28) = 21.94, P ≤ 0.0001] but not olcegepant [F(2,28) = 1.38, P = 0.27] reduced orofacial mechanical withdrawal thresholds (A) out to Day 7 (B). *P < 0.05, n = 8 mice per group.
