Table 1.
Selected eAGR2 associating proteins identified by AP–MS/MS
| GO | Protein | Description | SAINT | Protein ID’s | GO | Protein | Description | SAINT | Protein ID’s |
|---|---|---|---|---|---|---|---|---|---|
| Signaling receptor binding | MAGI2 | Membrane associated guanylate kinase, WW and PDZ domain containing 2 | 1.00 | 40 | Nucleic acid binding | ELAVL3 | ELAV like RNA binding protein 3 | 1.00 | 21 |
| C3 | Complement C3 | 1.00 | 22 | MLL3 | Lysine methyltransferase 2C | 1.00 | 7 | ||
| AGR2 | Anterior gradient 2, protein disulfide isomerase family member | 1.00 | 21 | PRKCSH | Protein kinase C substrate 80K-H | 1.00 | 7 | ||
| DST | Dystonin | 1.00 | 7 | RNF20 | Ring finger protein 20 | 1.00 | 5 | ||
| TLN1 | Talin 1 | 1.00 | 7 | SALL1 | Spalt like transcription factor 1 | 1.00 | 5 | ||
| SDHAF1 | Succinate dehydrogenase complex assembly factor 1 | 1.00 | 6 | SCML2 | Scm polycomb group protein like 2 | 1.00 | 5 | ||
| VWF | von Willebrand factor | 1.00 | 5 | ZNF512B | Zinc finger protein 512B | 0.99 | 5 | ||
| CNOT1 | CCR4-NOT transcription complex subunit 1 | 1.00 | 3 | INSM2 | INSM transcriptional repressor 2 | 1.00 | 4 | ||
| DOCK4 | Dedicator of cytokinesis 4 | 1.00 | 3 | MKI67 | Marker of proliferation Ki-67 | 0.99 | 3 | ||
| TRIP 12 | Thyroid hormone receptor interactor 12 | 1.00 | 3 | MLL | Lysine methyltransferase 2A | 0.98 | 2 | ||
| LAMB2 | Laminin subunit beta 2 | 0.98 | 2 | NUCB1 | Nucleobindin 1 | 0.97 | 2 | ||
| TACC2 | Transforming acidic coiled-coil containing protein 2 | 0.98 | 2 | ZNF285A | Zinc finger protein 285 | 0.98 | 2 | ||
| Structural molécula | AKAP6 | A-kinase anchoring protein 6 | 1.00 | 42 | Prot. domain binding | HOXC4 | Homeobox C4 | 1.00 | 8 |
| COL15A1 | Collagen type XV alpha 1 chain | 1.00 | 10 | HOXC6 | Homeobox C6 | 1.00 | 4 | ||
| Clorf68 | Chromosome 1 open reading frame 68 | 1.00 | 5 | SH3PXD2B | SH3 and PX domains 2B | 1.00 | 4 | ||
| COL4A4 | Collagen type IV alpha 4 chain | 0.99 | 3 | SRRM2 | Serine/arginine repetitive matrix 2 | 0.98 | 2 | ||
| COL6A1 | Collagen type VI alpha 1 chain | 0.97 | 2 | Intermediate filament | COL11A1 | Collagen type XI alpha 1 chain | 1.00 | 4 | |
| GTPase Binding | EXOC2 | Exocyst complex component 2 | 1.00 | 8 | COL5A3 | Collagen type V alpha 3 chain | 1.00 | 7 | |
| DIAPH3 | Diaphanous related formin 3 | 1.00 | 6 | COL4A3 | Collagen type IV alpha 3 chain | 1.00 | 6 | ||
| RIMS4 | Regulating synaptic membrane exocytosis 4 | 1.00 | 6 | EPPK1 | Epiplakin 1 | 1.00 | 6 | ||
| Miscellaneous | ADH5 | Alcohol dehydrogenase 5 (class III), chi polypeptide | 1.00 | 9 | Miscellaneous | NAA35 | N(alpha)-acetyltransferase 35, NatC auxiliary subunit | 1.00 | 6 |
| COL4A6 | Collagen type IV alpha 6 chain | 1.00 | 9 | KIAA1486 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | 0.97 | 2 | ||
| TRPM1 | Transient receptor potential cation channel subfamily M member 1 | 1.00 | 7 | CSMD2 | CUB and Sushi multiple domains 2 | 1.00 | 6 | ||
| DCHS1 | Dachsous cadherin-related 1 | 0.98 | 2 | FAM179B | TOG array regulator of axonemal microtubules 1 | 1.00 | 11 | ||
| AKAP13 | A-kinase anchoring protein 13 | 1.00 | 165 | SPATA7 | Spermatogenesis associated 7 | 1.00 | 9 | ||
| FLJ43859 | SPATA31 subfamily D member 4 | 1.00 | 15 | MTUS2 | 1.00 | 5 | |||
| Microtubule associated scaffold protein 2 | |||||||||
| EHBP1 | EH domain binding protein 1 | 1.00 | 4 | COPS3 | COP9 signalosome subunit 3 | 1.00 | 4 | ||
| KJAA1529 | Coiled-coil domain containing 180 | 1.00 | 7 | CSPP1 | Centiosome and spindle pole associated protein 1 | 1.00 | 7 | ||
| CEP110 | Centriolin | 1.00 | 6 | RNFI23 | Ring finger protein 123 | 0.98 | 2 | ||
| FSD1L | Fibronectin type III and SPRY domain containing 1 like | 1.00 | 40 | TPSG1 | Tryptase gamma 1 | 1.00 | 12 | ||
| SPACA3 | Sperm acrosome associated 3 | 0.99 | 3 | AKAP6 | A-kinase anchoring protein 6 | 1.00 | 42 | ||
| TET1 | Tet methylcytosine dioxygenase 1 | 1.00 | 3 | FU317I3 | Unkown | 1.00 | 11 | ||
| LCK | LCK proto-oncogene, Src family tyrosine kinase | 0.99 | 3 | LOC441722 | Unkown | 0.99 | 3 |
For each interacting protein, the number of protein counts (FDR < 0.05) and corresponding SAINT score is given. Gene ontology molecular function is listed